Cellular and humoral immunity in the pathogenesis of recurrent herpes viral infections in patients with

These data demonstrate that administration of a relatively mild stressor is associated with depressed HSV-specific cellular and humoral immunity and is associated with increased pathogenicity. Full text Full text is available as a scanned copy of the original print version. For example, if the current year is 2008 and a journal has a 5 year moving wall, articles from the year 2002 are available. Better preservation of cellular immunity to herpes simplex antigen during treatment was associated with infrequent reactivation of herpes simplex. Both TNF-alpha(-/-) and IFN-gamma(-/-) mice were protected against IVAG HSV-2 challenge following local delivery of poly(I:C). Kinetic analysis demonstrated that as soon as the infected cells began to express HSV glycoproteins on their surface they became susceptible to this enhanced killing. For example, if the current year is 2008 and a journal has a 5 year moving wall, articles from the year 2002 are available.

In contrast to Daxx and Sp100, however, the recruitment of PIAS1 is enhanced by PML. Furthermore, the pattern of HSV-2 infection is similar with other Sexual Transmitted Disease (STD). Following challenge with HSV-1, immune competent mice primed with recombinant Lm expressing gB498−505 antigen were protected from HSV-induced paralysis. We found no significant differences in the up-regulation of major histocompatibility complex (MHC) class II antigens in the epithelium, up-regulation of vascular cell adhesion molecule-1 (VCAM-1) in vascular endothelium, or recruitment of T cells to the mucosa, indicating that the memory T-cell response to virus challenge was the same in intact and B-cell KO mice. Patients who did not develop recurrent disease following primary HSV-2 genital infection were LIF positive at greater than or equal to 30 days. Full text Full text is available as a scanned copy of the original print version. We conclude that natural resistance operates at a level of virus handling prior to operation of the lymphocyte system, perhaps at the generation of interferon.

Cutaneous complications occurred more frequently in the severely immunocompromised group than in the other two groups (P < 0.01). Herpes simplex infection occurred in 95 percent of seropositive patients but decreased after 12 weeks. Accordingly, BALB/c responses showed antigen-induced cytokine profiles dominated by type 1 cytokines, whereas C57BL/6 and C3H/HeN mice generated cytokine responses mainly of the type 2 variety. Seventy long-term survivors of marrow transplant were also studied. Here we will review the current knowledge on the role of DCs in the host immune response to primary HSV infection. Recent developments in immunology reveal that the mammalian innate immune systems use Toll-like receptor (TLR) to specifically sense evolutionary conserved molecules such as bacterial DNA in pathogens. Our studies indicate that the immune responses of mice to live virus differ greatly from the responses to inactivated virus even when the virus does not complete a replicative cycle. Supernatants obtained during recrudescence, but not those obtained during convalescence, quiescence, or from seropositive controls, failed to augment natural killer activity but contained interferon and interleukin-2. In contrast, the adoptive transfer of DTH using draining lymph node cells was only possible during the period 6 to 10 days p.i. This study investigated the potential of transcutaneous immunisation in C3H mice, using CT co-administered with whole inactivated HSV-1 (CT+HSVi) or HSV-1 antigens extracted from infected Vero cells (CT+HSVag) or a control protein (CT+BSA). SummaryHerpes simplex virus type 2 (HSV-2) infection is the most common cause of genital ulcerative disease in the developed world. This article has been cited by other articles in PMC. The immunogenicity of a DNA free herpes simplex subunit vaccine was evaluated in chimpanzees and rabbits. This article has been cited by other articles in PMC. The potential of nontoxic recombinant B subunits of cholera toxin (rCtxB) and its close relative Escherichia coli heat-labile enterotoxin (rEtxB) to act as mucosal adjuvants for intranasal immunization with herpes simplex virus type 1 (HSV-1) glycoproteins was assessed. The frequency of varicella-zoster virus (VZV)-specific T lymphocytes was higher in elderly subjects who had herpes zoster infections than in age-matched controls. 86 patients with lymphoma were evaluated prospectively for clinical and laboratory evidence of recurrent varicella-zoster, herpes simplex, and cytomegalovirus infections during the first 16 mo of treatment. Neonates are severely compromised in the ability to generate an immune response to pathogens and thus rely heavily on maternally derived immunity that is acquired by transplacental and transmammary means. Cell-mediated immune responses to herpes simplex virus 1 and type 2 virion and non-virion antigens were assessed in patients and in controls with oral leukoplakia, carcinoma and recurrent herpes labialis. Cell-mediated immunity to herpes simplex virus type 1 (HSV-1) was assessed by a lymphocytotoxicity 51-Cr-release microassay procedure, using the MA-160 human prostatic adenoma cell line chronically infected with HSV-1 and its parent cell line as control. Studies with human volunteers and patients suffering from recurrent herpes simplex virus (HSV) infections have shown that reinfections with autologous or heterologous strains, occurring at sites distant from those of the recurrences, are possible in a variable proportion of the subjects.

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