Chronic Joint Disease Caused by Persistent Chikungunya Virus Infection Is Controlled by the Adaptive Immune

It more commonly affects women than men. Philadelphia, PA: Elsevier Saunders; 2013:chap 110. This rash may or may not itch and usually goes away within 10 days. About 60 percent of adults have been infected with it at some point in their lives. The next step is coordinating treatment for both the virus and the related joint problems. The virus infected one-third of the population, or 260,000 people. Philadelphia, PA: Elsevier Saunders; 2013:chap 44.

Because the tick bite often goes unnoticed and the rash may be overlooked, Lyme disease is not always diagnosed immediately. systemic lupus erythematosus, Behcet’s disease; Other systemic illnesses, e.g. Almost 80 percent of adults who get fifth disease report sore joints within three weeks of the infection. Until 2004, CHIKV was known to cause debilitating rheumatologic disease in many parts of Sub-Saharan Africa and Asia (5). Chronic inflammation of the joint lining, known as synovitis, can develop in people who have chronic active hepatitis. There are concerns that travellers returning from the World Cup in Brazil will bring the illness home with them as well. These drugs include synthetic proteins that bind to a cytokine called TNF-alpha and block its role in inflammation.


Among these causes: traumatic (sprain, dislocation, fracture etc.) intra- or postinfectious causes (septic arthritis, osteomyelitis, viral arthritis, poststreptococcal arthritis etc.), inflammatory/immunological causes (transient synovitis, reactive arthritis, etc.), tumors (bone tumors, metastases, etc.), degenerative diseases (Legg Calve Perthes disease, osteochondritis dissecans etc.). This results in inflammation of tissues and damage to the body cells. Some people do not know they have been bitten, making diagnosis challenging. Outbreaks have since been recorded in France and Croatia. Until 2004, CHIKV was known to cause debilitating rheumatologic disease in many parts of Sub-Saharan Africa and Asia (5). These results suggest that viral load at the acute phase may determine the pattern and amount of cytokine secretion, and that high levels of specific pro-inflammatory cytokines in the chronic phase of the disease provides a possible explanation for the persistence of joint pain. The hands and knees are the most common sites, but the wrists, ankles, elbows, shoulders, and other large joints are also affected.

This can result in joint swelling, pain, and stiffness. If you think you may have a medical emergency, call your doctor or (in the United States) 911 immediately. You should be able to manage injury-related swelling at home with anti-inflammatories, an icepack and rest. About 20 percent of people who get the virus don’t have symptoms, but they can still pass the virus along to others. This is termed symmetric arthritis. I saw my primary doc who told me all my autoimmune tests that were done at the hospital were negative (even my sed rate was normal) and since I had no swelling in my joints that I probably had some kind of virus. Some common conditions that may cause joint pain include systemic lupus erythematosus (SLE), psoriasis, hepatitis, inflammatory bowel disease, and Lyme disease.

In about half of all cases, infectious arthritis involves the knee, but hips, ankles and wrists are also commonly affected. Its clinical presentation can mimic rheumatoid arthritis however the joint involvement is typically ‘non destructive’ [2]. Patients did not have rheumatoid arthritis at the beginning of the study, but cases were documented as they were diagnosed throughout the course of the study. At present there is no known cure. There are other things that could be going on, too, but that’s the one that I know about! About 60 percent of adults have been infected with it at some point in their lives. In general, infectious arthritis is caused by the spread of a bacterial, viral, or fungal infection through the bloodstream to the joint.

Because a joint that is damaged is more vulnerable to germs, people with existing disease involving the joints (for example, rheumatoid arthritis * ) are more likely to develop infectious arthritis. (It’s called this because it was first diagnosed in a child in Old Lyme, Connecticut.) This infection often starts with a red mark that is surrounded by a light ring or halo, which occurs on the skin at the site where your child was bitten by the tick. Louis and a key US researcher of CHIKV infection. They were evaluated seven to 10 weeks after symptoms began and compared with people who had rheumatoid arthritis. Bacteria are carried by the bloodstream from an infectious focus elsewhere, introduced by a skin lesion that penetrates the joint, or by extension from adjacent tissue (e.g. “It’s more wear and tear of the cartilage between the joints.” Lupus, like RA, is an inflammatory autoimmune disorder. Miranda’s story is similar to the story of Lizzie Morales, of Houston, Texas, who told ABC’s Houston station KTRK-TV that she was infected with Zika when she was in El Salvador to visit family for Christmas.

Leave a Reply